GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330470/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330470GEOGSEfalseChIP-seq and CUT&Tag profiling of the genome binding of YAP/TAZ-TEAD and SMAD3 in the human HCC cell line HCCLM3 [ChIP-seq]This study generated ChIP-seq and CUT&Tag datasets to profile genome-wide occupancy of YAP, TAZ, TEAD1, SMAD3, and VGLL4 in the human hepatocellular carcinoma cell line HCCLM3. Profiling was performed under four conditions: untreated control, TGF-beta1 stimulation (2.5 ng/ml for 2 h), siRNA-mediated knockdown of YAP and TAZ followed by TGF-beta1 stimulation (2.5 ng/ml for 2 h), and stable KLF2 overexpression followed by TGF-beta1 stimulation (2.5 ng/ml for 2 h). ChIP-seq was also used to profile the histone modifications H3K27ac, H3K4me1, H3K4me3, and H3K18la. These datasets provide a resource for studying transcription factor binding and chromatin states in HCCLM3 cells.2026/05/16GSE330470GSM9727310GSM9727311GSM9727312GSM9727313GSM9727314GSM9727315GSM9727316GSM9727317GSM9727318GSM9727319GSM9727284GSM9727285GSM9727286GSM9727320GSM9727287GSM9727288GSM9727321GSM9727289GSM9727322GSM9727323GSM9727324GSM9727325GSM9727326GSM9727327GSM9727328GSM9727329GSM9727290GSM9727291GSM9727292GSM9727293GSM9727294GSM9727295GSM9727296GSM9727297GSM9727330GSM9727331GSM9727298GSM9727332GSM9727299GSM9727333GSM9727334GSM9727335GSM9727336GSM9727337GSM9727338GSM9727300GSM9727301GSM9727302GSM9727303GSM9727304GSM9727305GSM9727306GSM9727307GSM9727308GSM972730924676330470Homo sapiens