{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330672"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Catechol-O-methyltransferase attenuates invasive potential by upregulating desmogleins and is associated with better prognosis in ovarian cancer","description":"Catechol-O-methyltransferase (COMT) is a key enzyme in estrogen catabolism, but its estrogen-independent roles in ovarian cancer remain largely unknown. This study aims to elucidate the molecular mechanisms by which COMT suppresses cell invasion and to evaluate its significance as a prognostic marker. We performed transcriptome analysis (RNA-seq) on ovarian cancer cells to identify downstream targets of COMT. Our results show that COMT overexpression significantly inhibits cell invasion in an estrogen-independent manner. Integrative analysis of RNA-seq and CE-MS metabolome data revealed that COMT upregulates desmoglein genes (DSG1-3), thereby strengthening cell-to-cell contact, and induces metabolic remodeling. These findings suggest that COMT suppresses metastasis by regulating cell adhesion and metabolism, serving as a potential prognostic marker and therapeutic target in ovarian cancer.","dates":{"publication":"2026/05/26"},"accession":"GSE330672","cross_references":{"GSM":["GSM9730114","GSM9730113","GSM9730112","GSM9730111"],"GPL":["23227"],"GSE":["330672"],"taxon":["Homo sapiens"]}}