{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330837/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330837"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Active repression of muscle fate preserves neural lineage identity during cerebellum development","description":"Cell fate commitment is commonly thought to entail progressive restriction of developmental potential, enforced by passive, heterochromatin-based silencing of alternative lineage programs. Here we show that maintenance of neural identity during cerebellum development instead requires active repression of a starkly divergent fate by the TEAD–INSM1 transcriptional complex. Loss of TEAD1/2 or INSM1 activates the myogenic master regulator Myod1, resulting in neural cells acquiring transcriptional, structural, and metabolic features of skeletal muscle cells. Deletion of Myod1 fully suppresses neural-to-muscle conversion while partially rescuing neural developmental defects. Our results uncover a latent alternative lineage during neurodevelopment and a surprising role for sequence-specific transcription factors in enforcing lineage boundaries, including those previously thought essentially unbreachable, with implications for understanding aberrant differentiation in disease contexts and cell-type evolution.","dates":{"publication":"2026/06/30"},"accession":"GSE330837","cross_references":{"GSM":["GSM9733392","GSM9733391","GSM9733394","GSM9733393","GSM9733390","GSM9733399","GSM9733396","GSM9733395","GSM9733398","GSM9733397","GSM9733408","GSM9733407","GSM9733409","GSM9733404","GSM9733403","GSM9733406","GSM9733405","GSM9733400","GSM9733402","GSM9733401","GSM9733372","GSM9733419","GSM9733418","GSM9733415","GSM9733414","GSM9733417","GSM9733416","GSM9733378","GSM9733411","GSM9733410","GSM9733377","GSM9733413","GSM9733379","GSM9733412","GSM9733374","GSM9733373","GSM9733376","GSM9733375","GSM9733381","GSM9733380","GSM9733383","GSM9733382","GSM9733422","GSM9733389","GSM9733421","GSM9733388","GSM9733424","GSM9733423","GSM9733385","GSM9733384","GSM9733387","GSM9733420","GSM9733386"],"GPL":["34290"],"GSE":["330837"],"taxon":["Mus musculus"],"PMID":["[42182376]"]}}