GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330843/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330843GEOGSEfalseThe CRAC channel inhibitor Auxora interrupts inflammatory circuits between alveolar macrophages and T cells in patients with viral pneumoniaViral pneumonia is perpetuated by inflammatory circuits between activated T cells and monocyte-derived alveolar macrophages (MoAM). T cells and macrophages express ORAI1 and STIM1, which form calcium release-activated calcium (CRAC) channels that allow extracellular calcium entry in response to endoplasmic reticulum calcium store depletion. In a randomized, placebo-controlled, multicenter phase 2 trial (CARDEA), Auxora, a CRAC channel inhibitor, reduced all-cause 30-day mortality by 56% in patients with severe SARS-CoV-2 pneumonia1. Here, we report a multi-omics analysis of serially collected alveolar samples from unvaccinated patients with severe SARS-CoV-2 pneumonia treated with Auxora versus placebo. We found reductions in plasma levels of the monocyte- and T cell-chemokines, CCL8 and CXCL10. Using PBMCs from healthy volunteers, we show Auxora directly targets T cells to inhibit the transcription of CCL8 and CXCL10 in monocyte-derived macrophages, supporting a mechanism for its effects and a potential intermediate biomarker of efficacy.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 sapiens