{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330905/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330905"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Targeting the Calcineurin Homologous Protein 1 (CHP1)-Transmembrane Protein 87A (TMEM87A) Mechanosensing Complex: A Druggable Vulnerability in Metastatic Ovarian Cancer","description":"Bulk RNA-seq was performed to investigate transcriptomic changes upon CRISPR-mediated knockout of CHP1 or TMEM87A in OVCAR8 human ovarian cancer cells (in vitro), and to assess the effect of gluconate treatment versus PBS control in an OVCAR8-NSG orthotopic tumor model (in vivo). Three independent biological replicates were profiled per condition.","dates":{"publication":"2026/05/31"},"accession":"GSE330905","cross_references":{"GSM":["GSM9735494","GSM9735483","GSM9735484","GSM9735495","GSM9735492","GSM9735493","GSM9735490","GSM9735491","GSM9735502","GSM9735500","GSM9735489","GSM9735501","GSM9735498","GSM9735487","GSM9735488","GSM9735499","GSM9735485","GSM9735496","GSM9735497","GSM9735486"],"GPL":["24676"],"GSE":["330905"],"taxon":["Homo sapiens"],"PMID":["[42258092]"]}}