{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331007/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331007"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effects of T cell–specific IL-21 isoform expression on gene expression in mammary epithelial cells.","description":"Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4⁺ T cells that critically regulates the differentiation and functions of various adaptive and innate immune cells. In this study, to investigate the chronic effects of IL-21 on gene expression in mammary epithelial cells (MECs), MECs were isolated from 10-week-old transgenic mice expressing a membrane-bound IL-21 isoform specifically in T cells (IL-21isoTg) and subjected to RNA sequencing analysis, followed by comparison with wild-type controls. IL-21isoTg MECs showed marked upregulation of genes associated with mammary gland development and lactation and Spp1.","dates":{"publication":"2026/05/18"},"accession":"GSE331007","cross_references":{"GSM":["GSM9737277","GSM9737276","GSM9737275","GSM9737280","GSM9737279","GSM9737278"],"GPL":["24247"],"GSE":["331007"],"taxon":["Mus musculus"]}}