{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331107"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The transcription factor AFF3 is necessary to maintain metabolic quiescence in naïve CD8 T cells and prevent premature immune aging","description":"Naïve CD8 T cells must be maintained in a quiescent metabolic state in order to respond robustly to infection while avoiding inappropriate activation and causing immunopathology. With age this quiescent state is lost and the CD8 T cell response to infection decreases. The factors regulating metabolic quiescence of CD8 T cells and how this regulation is lost during aging are not completely understood. Herein, we identify the transcription factor AFF3 as a novel regulator of metabolic quiescence in naïve CD8 T cells. While naïve AFF3 deficient CD8 T cells are more metabolically active prior to infection, they have reduced accumulation in response to viral infection and this is correlated with a poor capacity to engage glycolysis. During aging in both murine and human CD8 T cells, AFF3 expression is reducing, correlating with to a loss of quiescent metabolism without the cells entering an activated state. Our data highlights the role of the metabolism in CD8 T cell quiescence and identifies a novel transcription factor that may be a target to reinvigorate CD8 T cell responses during aging.","dates":{"publication":"2026/06/01"},"accession":"GSE331107","cross_references":{"GSM":["GSM9739114","GSM9739136","GSM9739135","GSM9739113","GSM9739134","GSM9739112","GSM9739111","GSM9739133","GSM9739132","GSM9739110","GSM9739131","GSM9739130","GSM9739119","GSM9739118","GSM9739117","GSM9739116","GSM9739115","GSM9739125","GSM9739124","GSM9739123","GSM9739122","GSM9739121","GSM9739120","GSM9739109","GSM9739108","GSM9739129","GSM9739107","GSM9739128","GSM9739127","GSM9739126"],"GPL":["34290"],"GSE":["331107"],"taxon":["Mus musculus"]}}