{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331225/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331225"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"TRPV1–STAT3 signaling as a driver of lethal pathology during pneumococcal nose-to-brain invasion","description":"To investigate mechanisms underlying lethal pneumococcal nose-to-brain infection, we established a murine intranasal Streptococcus pneumoniae infection model with methimazole-induced olfactory epithelial injury and/or resiniferatoxin-mediated trigeminal TRPV1 ablation. Spatial transcriptomic analysis identified a distinct inflammatory transcriptional cluster localized to the olfactory epithelium and adjacent olfactory bulb in methimazole-treated mice. The cluster showed enrichment of STAT3-associated transcriptional programs and inflammatory pathways. These findings suggest that olfactory epithelial injury and trigeminal TRPV1 signaling contribute to localized inflammatory responses during pneumococcal nose-to-brain invasion.","dates":{"publication":"2026/08/19"},"accession":"GSE331225","cross_references":{"GSM":["GSM9742275","GSM9742276"],"GPL":["24247"],"GSE":["331225"],"taxon":["Mus musculus"]}}