{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331241"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood brain barrier disruption","description":"This study investigated how endothelial Serpine1/PAI-1 signalling influences cerebral blood flow and functional recovery after stroke. Contrary to expectations, endothelial Serpine1 knockdown reduced peri-infarct capillary flow yet improved blood-brain barrier integrity, reduced inflammation, and enhanced functional recovery, suggesting that carefully regulating — rather than maximizing — post-stroke blood flow may promote recovery.","dates":{"publication":"2026/05/20"},"accession":"GSE331241","cross_references":{"GSM":["GSM9742425","GSM9742426","GSM9742423","GSM9742424","GSM9742418","GSM9742429","GSM9742419","GSM9742427","GSM9742428","GSM9742421","GSM9742422","GSM9742420"],"GPL":["28383"],"GSE":["331241"],"taxon":["Mus musculus"]}}