GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331241/primaryOK200TranscriptomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331241GEOGSEfalseKnockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood brain barrier disruptionThis study investigated how endothelial Serpine1/PAI-1 signalling influences cerebral blood flow and functional recovery after stroke. Contrary to expectations, endothelial Serpine1 knockdown reduced peri-infarct capillary flow yet improved blood-brain barrier integrity, reduced inflammation, and enhanced functional recovery, suggesting that carefully regulating — rather than maximizing — post-stroke blood flow may promote recovery.2026/05/20GSE331241GSM9742425GSM9742426GSM9742423GSM9742424GSM9742418GSM9742429GSM9742419GSM9742427GSM9742428GSM9742421GSM9742422GSM974242028383331241Mus musculus