{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331294/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331294"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-nucleus RNA-seq analysis of whole brains from 5xFAD mice with microglia-specific CD31 knockdown","description":"We performed single-nucleus RNA sequencing (snRNA-seq) on whole-brain tissues from 5xFAD mice with microglia-specific CD31 knockdown to investigate transcriptional alterations associated with Alzheimer’s disease pathology. snRNA-seq analysis identified cell-type-specific transcriptional changes across multiple brain cell populations, including microglia, revealing that CD31 knockdown attenuated disease-associated microglial signatures and inflammatory responses while promoting pathways related to Aβ clearance. These findings provide insights into the role of microglial CD31 in regulating neuroinflammation and Alzheimer’s disease progression.","dates":{"publication":"2026/05/23"},"accession":"GSE331294","cross_references":{"GSM":["GSM9743349","GSM9743348","GSM9743347","GSM9743342","GSM9743350","GSM9743346","GSM9743345","GSM9743344","GSM9743343"],"GPL":["24247"],"GSE":["331294"],"taxon":["Mus musculus"]}}