{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331322/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331322"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Antibodies derived from patient tumors augment response to immune checkpoint blockade in cancer","description":"B-cells are associated with favorable response to immunotherapy, though the underlying mechanisms remain unclear. Here, we profiled tumor-infiltrating B-cells (TIL-Bs) and tertiary lymphoid structures (TLS) from α-PD-1 + α-CTLA-4 treated responders (R) and non-responders (NR) to identify immune signatures. TLS from responders exhibited upregulated inflammatory genes, and increased levels of cytotoxic immune cells.","dates":{"publication":"2026/08/20"},"accession":"GSE331322","cross_references":{"GSM":["GSM9743889","GSM9743888","GSM9743887","GSM9743898","GSM9743897","GSM9743886","GSM9743892","GSM9743891","GSM9743890","GSM9743885","GSM9743896","GSM9743884","GSM9743895","GSM9743894","GSM9743883","GSM9743893"],"GPL":["24676"],"GSE":["331322"],"taxon":["Homo sapiens"]}}