GEOTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331381GEOGSEfalseEffect of genetic background and limb immobilization on tibial metaphysis transcriptomes in 19‑week male miceThis study profiles tibial metaphysis RNA expression across eight inbred mouse strains subjected to unilateral hindlimb immobilization. RNA‑seq was performed on metaphyseal tissue from immobilized and contralateral control limbs to identify strain‑specific transcriptional responses to mechanical unloading. Differential expression analysis revealed distinct genetic‑background–dependent signatures associated with bone remodeling, inflammation, and mechanotransduction pathways.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 musculus