GEOTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331452GEOGSEfalseDICER-Driven Regulation of Lipid Metabolism and Macrophage-Adipocyte Crosstalk in Partial LipodystrophyPartial lipodystrophy is characterized by abnormal fat distribution, impaired thermogenesis, systemic inflammation, and diminished DICER expression in adipose tissue. Using adipocyte-specific DICER-deficient models to mimic lipodystrophy, we identified early metabolic and inflammatory alterations that coincide with the onset of partial lipodystrophy. DICER deficiency in adipocytes impaired lipid metabolism, leading to increased release of saturated lipids and triglycerides into the medium while reducing the biosynthesis of anti-inflammatory lipids. These changes promoted a pro-inflammatory environment by reprogramming macrophages to release IL-1beta. Lipidomic analyses revealed reduced levels of docosahexaenoic acid (DHA) and other polyunsaturated fatty acids (PUFAs) in DICER-deficient adipocytes, accompanied by increased expression of CYP450 enzymes linked to lipid degradation and reduced DHA biosynthesis. DHA supplementation mitigated the pro-inflammatory response triggered by conditioned media from DICER-deficient adipocytes.2026/06/01GSE331452GSM9746052GSM9746050GSM9746051GSM9746049GSM9746047GSM974604824247331452Mus musculus