{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331524/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331524"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic analysis of hippocampus and prefrontal cortex in a mouse model of chronic radiation-induced gastrointestinal injury","description":"Chronic radiation-induced gastrointestinal injury is associated with persistent gut dysfunction and microbiome alterations, which may contribute to extra-intestinal complications including neurovascular and behavioral abnormalities. To investigate molecular changes in the brain during chronic radiation-induced intestinal injury, RNA sequencing was performed using hippocampal and prefrontal cortex tissues collected from irradiated mice and non-irradiated controls. Transcriptomic profiling revealed region-specific alterations, with the hippocampus showing more pronounced changes in pathways related to vascular remodeling, extracellular matrix organization, inflammatory response, and blood–brain barrier dysfunction. These datasets provide a resource for understanding gut–brain axis-associated molecular alterations in chronic radiation-induced injury.","dates":{"publication":"2026/05/25"},"accession":"GSE331524","cross_references":{"GSM":["GSM9749123","GSM9749124","GSM9749121","GSM9749122","GSM9749120","GSM9749129","GSM9749118","GSM9749119","GSM9749127","GSM9749128","GSM9749125","GSM9749126"],"GPL":["24247"],"GSE":["331524"],"taxon":["Mus musculus"]}}