GEOTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331524GEOGSEfalseTranscriptomic analysis of hippocampus and prefrontal cortex in a mouse model of chronic radiation-induced gastrointestinal injuryChronic radiation-induced gastrointestinal injury is associated with persistent gut dysfunction and microbiome alterations, which may contribute to extra-intestinal complications including neurovascular and behavioral abnormalities. To investigate molecular changes in the brain during chronic radiation-induced intestinal injury, RNA sequencing was performed using hippocampal and prefrontal cortex tissues collected from irradiated mice and non-irradiated controls. Transcriptomic profiling revealed region-specific alterations, with the hippocampus showing more pronounced changes in pathways related to vascular remodeling, extracellular matrix organization, inflammatory response, and blood–brain barrier dysfunction. These datasets provide a resource for understanding gut–brain axis-associated molecular alterations in chronic radiation-induced injury.2026/05/25GSE331524GSM9749123GSM9749124GSM9749121GSM9749122GSM9749120GSM9749129GSM9749118GSM9749119GSM9749127GSM9749128GSM9749125GSM974912624247331524Mus musculus