GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE332nnn/GSE332556/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE332556GEOGSEfalseTumor-associated Macrophage GnT-V Enhances Sensitivity to Antitumor Immunotherapy through Branched N-Glycosylation to Promote M1 PolarizationTumor tissues with differential sensitivity to immunotherapy were sequenced using The DNBelab C4 /DNBelab TaiM4 Series Single-Cell Library Prep Set (MGI) was used for sequencing and sequenced on the DNBSEQ-T7 sequencer with pair-end sequencing. Immunotherapy based on immune checkpoint inhibitors (ICIs) has become one of the most successful clinical treatment strategies and has marked a milestone in the field of cancer therapy. Regrettably, the complex immunosuppressive network within the tumor microenvironment (TME), characterized by imbalanced immune cell subsets and suppressed immune cell function, represents a major cause of ICI treatment failure. This study, through single-cell analysis, provides mechanistic insights into TAM polarization and establishes the therapeutic feasibility of targeting this regulatory axis, thereby introducing a novel treatment strategy to benefit cancer patients.2026/05/25GSE332556GSM9750658GSM975065929480332556Homo sapiens