{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE332646"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Bulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints","description":"Transcriptomic profiling of mouse liver tissue to characterize the acute and long-term gene expression response to the carcinogen N-nitrosodimethylamine (NDMA) in juvenile mice. RaDR+/+;GPT+/+ (WT) and RaDR+/+;GPT+/+;Mgmt-/- (Mgmt knockout) mice received intraperitoneal injections of NDMA (3.5 mg/kg at postnatal day 8 and 7 mg/kg at postnatal day 15) or saline vehicle. Liver tissue was collected at Day 1, Day 2, Day 5, Week 10, and Month 10 post-treatment and subjected to bulk RNA-seq to identify differential gene expression patterns across genotypes, sexes, treatments, and timepoints.","dates":{"publication":"2026/05/22"},"accession":"GSE332646","cross_references":{"GSM":["GSM9751900","GSM9751901","GSM9751935","GSM9751936","GSM9751937","GSM9751938","GSM9751939","GSM9751940","GSM9751941","GSM9751942","GSM9751943","GSM9751944","GSM9751823","GSM9751824","GSM9751945","GSM9751924","GSM9751925","GSM9751926","GSM9751927","GSM9751928","GSM9751929","GSM9751930","GSM9751931","GSM9751932","GSM9751933","GSM9751934","GSM9751913","GSM9751914","GSM9751915","GSM9751916","GSM9751917","GSM9751918","GSM9751919","GSM9751920","GSM9751921","GSM9751922","GSM9751923","GSM9751902","GSM9751903","GSM9751904","GSM9751905","GSM9751906","GSM9751907","GSM9751908","GSM9751909","GSM9751910","GSM9751911","GSM9751912","GSM9751858","GSM9751979","GSM9751859","GSM9751861","GSM9751982","GSM9751862","GSM9751983","GSM9751984","GSM9751863","GSM9751864","GSM9751985","GSM9751865","GSM9751986","GSM9751987","GSM9751866","GSM9751867","GSM9751988","GSM9751868","GSM9751989","GSM9752030","GSM9752031","GSM9752032","GSM9752033","GSM9752034","GSM9751980","GSM9752035","GSM9751981","GSM9752036","GSM9751860","GSM9751847","GSM9751968","GSM9751848","GSM9751969","GSM9751849","GSM9751850","GSM9751971","GSM9752026","GSM9752027","GSM9751851","GSM9751972","GSM9751852","GSM9751973","GSM9752028","GSM9751853","GSM9751974","GSM9752029","GSM9751975","GSM9751854","GSM9751855","GSM9751976","GSM9751856","GSM9751977","GSM9751978","GSM9751857","GSM9752020","GSM9752021","GSM9752022","GSM9752023","GSM9752024","GSM9751970","GSM9752025","GSM9751836","GSM9751957","GSM9751958","GSM9751837","GSM9751838","GSM9751959","GSM9751839","GSM9751960","GSM9752015","GSM9751961","GSM9752016","GSM9751840","GSM9751841","GSM9751962","GSM9752017","GSM9752018","GSM9751842","GSM9751963","GSM9751964","GSM9752019","GSM9751843","GSM9751844","GSM9751965","GSM9751845","GSM9751966","GSM9751967","GSM9751846","GSM9752010","GSM9752011","GSM9752012","GSM9752013","GSM9752014","GSM9751825","GSM9751946","GSM9751947","GSM9751826","GSM9751827","GSM9751948","GSM9751828","GSM9751949","GSM9751829","GSM9752004","GSM9751950","GSM9752005","GSM9751830","GSM9751951","GSM9752006","GSM9752007","GSM9751831","GSM9751952","GSM9751832","GSM9751953","GSM9752008","GSM9751833","GSM9751954","GSM9752009","GSM9751955","GSM9751834","GSM9751835","GSM9751956","GSM9752000","GSM9752001","GSM9752002","GSM9752003","GSM9751894","GSM9751895","GSM9751896","GSM9751897","GSM9751898","GSM9751899","GSM9751890","GSM9751891","GSM9751892","GSM9751893","GSM9751883","GSM9751884","GSM9751885","GSM9751886","GSM9751887","GSM9751888","GSM9751889","GSM9751880","GSM9751881","GSM9751882","GSM9751869","GSM9751872","GSM9751993","GSM9751873","GSM9751994","GSM9751874","GSM9751995","GSM9751875","GSM9751996","GSM9751876","GSM9751997","GSM9751998","GSM9751877","GSM9751878","GSM9751999","GSM9751879","GSM9751990","GSM9751870","GSM9751991","GSM9751871","GSM9751992"],"GPL":["19057"],"GSE":["332646"],"taxon":["Mus musculus"]}}