{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE332nnn/GSE332663/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE332663"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of Cosmc-silenced Tn+ 4T1 cells-bearing triple-negative tumors in mice","description":"Aberrant O-glycosylation and accumulation of the Tn antigen are associated with aggressive phenotypes in triple-negative breast cancer (TNBC). To investigate the transcriptomic consequences of Tn antigen expression, we analyzed gene expression profiles of murine 4T1 breast cancer cells carrying CRISPR/Cas9-mediated silencing of the Cosmc gene (Tn+) compared with parental wild-type 4T1 cells (WT). Total RNA was extracted from 4T1 cells-bearing tumors from mice (Tn and WT)s and subjected to RNA sequencing using Illumina NovaSeq X technology.","dates":{"publication":"2026/06/10"},"accession":"GSE332663","cross_references":{"GSM":["GSM9752202","GSM9752203","GSM9752204","GSM9752205","GSM9752206","GSM9752195","GSM9752196","GSM9752197","GSM9752198","GSM9752199","GSM9752200","GSM9752201"],"GPL":["34328"],"GSE":["332663"],"taxon":["Mus musculus"]}}