{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE332nnn/GSE332837/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE332837"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell sequencing reveals NK cell dysregulation during chronic HIV infection and identifies transitional NK cell cytotoxicity related to HIV reservoir decay","description":"We performed scRNA-seq on NK cells from HCs and PLWH before/after ART. We identified ten subsets, including IFN-responding (c7) and proliferating (c8, c9) cells that expand in untreated PLWH. Cytotoxicity of the transitional NK before ART correlated with subsequent HIV-DNA decline. Our findings reveal NK cell heterogeneity during HIV infection, informing NK-based immunotherapies.","dates":{"publication":"2026/07/22"},"accession":"GSE332837","cross_references":{"GSM":["GSM9754090","GSM9754092","GSM9754091","GSM9754094","GSM9754093","GSM9754096","GSM9754095","GSM9754117","GSM9754116","GSM9754098","GSM9754097","GSM9754111","GSM9754110","GSM9754099","GSM9754113","GSM9754112","GSM9754079","GSM9754115","GSM9754114","GSM9754081","GSM9754080","GSM9754083","GSM9754082","GSM9754085","GSM9754084","GSM9754106","GSM9754105","GSM9754108","GSM9754107","GSM9754109","GSM9754087","GSM9754086","GSM9754089","GSM9754100","GSM9754088","GSM9754102","GSM9754101","GSM9754104","GSM9754103"],"GPL":["18573"],"GSE":["332837"],"taxon":["Homo sapiens"],"PMID":["[42475880]"]}}