{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE332nnn/GSE332845/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE332845"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Expression data of hippocampal neural stem cells from rat","description":"Neural stem cells (NSCs) are essential for brain development and adult hippocampal neurogenesis, yet early-life environmental stress may induce persistent dysfunction through epigenetic mechanisms. In this study, we investigated the long-term effects of maternal high-fructose corn syrup (HFCS) intake on NSCs using a rat DOHaD model. Maternal HFCS exposure induced persistent impairments in NSC proliferation and differentiation, accompanied by hippocampus-dependent cognitive dysfunction in offspring. Mechanistically, transient downregulation of Dnmt3a in fetal NSCs was associated with sustained repression of Spp1, encoding intracellular osteopontin (iOPN), a regulator of NSC function. We performed Affymetrix Clariom S microarray analyses of hippocampal NSCs isolated from offspring of control and maternal HFCS-fed rats and identified transcriptomic alterations associated with maternal HFCS exposure.","dates":{"publication":"2026/07/02"},"accession":"GSE332845","cross_references":{"GSM":["GSM9754270","GSM9754272","GSM9754271","GSM9754274","GSM9754273","GSM9754275","GSM9754269"],"GPL":["23040"],"GSE":["332845"],"taxon":["Rattus norvegicus"]}}