GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE332nnn/GSE332845/primaryOK200TranscriptomicsRattus norvegicusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE332845GEOGSEfalseExpression data of hippocampal neural stem cells from ratNeural stem cells (NSCs) are essential for brain development and adult hippocampal neurogenesis, yet early-life environmental stress may induce persistent dysfunction through epigenetic mechanisms. In this study, we investigated the long-term effects of maternal high-fructose corn syrup (HFCS) intake on NSCs using a rat DOHaD model. Maternal HFCS exposure induced persistent impairments in NSC proliferation and differentiation, accompanied by hippocampus-dependent cognitive dysfunction in offspring. Mechanistically, transient downregulation of Dnmt3a in fetal NSCs was associated with sustained repression of Spp1, encoding intracellular osteopontin (iOPN), a regulator of NSC function. We performed Affymetrix Clariom S microarray analyses of hippocampal NSCs isolated from offspring of control and maternal HFCS-fed rats and identified transcriptomic alterations associated with maternal HFCS exposure.2026/07/02GSE332845GSM9754270GSM9754272GSM9754271GSM9754274GSM9754273GSM9754275GSM975426923040332845Rattus norvegicus