GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333263/primaryOK200TranscriptomicsEscherichia coliExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333263GEOGSEfalseSoFIC Orchestrates Physical Barriers and Metabolic Homeostasis to Counter Phage InfectionBacteria have developed numerous defense systems to counter persistent phage infections. In this study, we characterize the SoFIC defense system, consisting of a Fic family protein. Our results show that SoFIC is widely distributed across multiple bacterial phyla and contains a conserved Fic catalytic motif essential for anti-phage activity.2026/05/30GSE333263GSM9759935GSM9759936GSM9759937GSM975993425368333263Escherichia coli