{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333370/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333370"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Loss of striatal astrocyte u-crystallin (Crym) contributes to early stage Huntington’s disease pathophysiology","description":"Astrocytes display regional heterogeneity in the brain, underscoring the need to study defined populations. A striatal astrocyte subpopulation expressing  crystallin (gene: Crym) regulates perseverative behaviors, but its role in disease is unclear. We found that astrocytic Crym and  crystallin protein expression levels are reduced significantly in human Huntington’s disease (HD) tissue and cerebrospinal fluid, and in HD mouse models. Selective astrocytic  crystallin restoration in R6/2 HD model mice improved astrocyte and neuronal morphology, electrophysiology, gene expression, and improved early stage cognitive and compulsive behaviors, though late stage motor deficits remained mostly unchanged. Approximately 32% of the  crystallin rescued astrocytic genes overlapped with those dysregulated in human HD, indicating conserved molecular corrections. These results identify  crystallin expressing astrocytes as modulators of HD pathophysiology and suggest that restoring  crystallin could be beneficial in early disease stages. The findings highlight the importance of identifying specific astrocyte subpopulations to understand and potentially treat brain disorders.","dates":{"publication":"2026/09/28"},"accession":"GSE333370","cross_references":{"GSM":["GSM9761594","GSM9761583","GSM9761595","GSM9761584","GSM9761592","GSM9761593","GSM9761582","GSM9761590","GSM9761591","GSM9761589","GSM9761587","GSM9761588","GSM9761596","GSM9761585","GSM9761597","GSM9761586"],"GPL":["21103"],"GSE":["333370"],"taxon":["Mus musculus"]}}