{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333394/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333394"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [scRNA-seq]","description":"Brain aging is associated with neurovascular uncoupling, blood-brain barrier (BBB) dysfunction, neuroinflammation, and cognitive decline. Brain endothelial cells are essential for maintaining BBB integrity and neurovascular homeostasis and are enriched for the transcription factor Krüppel-like factor 4 (KLF4). Because endothelial KLF4 expression declines with aging, we investigated whether endothelial KLF4 depletion contributes to age-associated neurovascular dysfunction and neuropsychiatric impairment.","dates":{"publication":"2026/05/28"},"accession":"GSE333394","cross_references":{"GSM":["GSM9762044","GSM9762043","GSM9762042","GSM9762041"],"GPL":["24247"],"GSE":["333394"],"taxon":["Mus musculus"]}}