{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333395/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333395"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ATAC-seq]","description":"Omni-ATAC sequencing was performed on purified brain endothelial nuclei from young and aged endothelial-specific Klf4 knockout (EC-K4KO) and WT Cre mice to investigate chromatin accessibility changes associated with endothelial aging and neurovascular dysfunction. Endothelial KLF4 loss induced chromatin remodeling enriched for inflammatory, stress-response, and senescence-associated pathways.","dates":{"publication":"2026/05/28"},"accession":"GSE333395","cross_references":{"GSM":["GSM9762046","GSM9762045","GSM9762055","GSM9762053","GSM9762051","GSM9762050","GSM9762049","GSM9762048","GSM9762047"],"GPL":["24247"],"GSE":["333395"],"taxon":["Mus musculus"]}}