GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333395/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333395GEOGSEfalseDepletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ATAC-seq]Omni-ATAC sequencing was performed on purified brain endothelial nuclei from young and aged endothelial-specific Klf4 knockout (EC-K4KO) and WT Cre mice to investigate chromatin accessibility changes associated with endothelial aging and neurovascular dysfunction. Endothelial KLF4 loss induced chromatin remodeling enriched for inflammatory, stress-response, and senescence-associated pathways.2026/05/28GSE333395GSM9762046GSM9762045GSM9762055GSM9762053GSM9762051GSM9762050GSM9762049GSM9762048GSM976204724247333395Mus musculus