GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333583/primaryOK200GenomicsCaenorhabditis elegansGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333583GEOGSEfalseDVE-1 is a telomere-binding protein and links the NuRD complex to telomere regulation in C. elegansTelomeres are repetitive DNA sequences at the end of linear chromosomes bound by specialized proteins. In our previous quantitative proteomics screen for telomere-binding proteins of Caenorhabditis elegans, we identified the homeobox protein DVE-1, a homolog of mammalian SATB proteins and transcription factor that plays a central role in the mitochondrial unfolded protein response, as a telomere repeat binding protein. Here, we validate DVE-1 as a telomere-binding protein in C. elegans, demonstrating in vitro binding of DVE-1 to the single-stranded C-rich telomeric sequence and in vivo co-localization with the known telomere binding protein POT-1 corroborated by ChIPseq analysis. RNA interference-mediated knockdown of DVE-1 resulted in reduced TERRA expression and enhanced compaction of telomeric chromatin. Subsequent transcriptomic and proteomic analyses suggest a role for DVE-1 in the regulation of telomeric chromatin organization. Finally, DVE-1 immunoprecipitation followed by mass spectrometry identified all core components of the nucleosome remodeling and deacetylase (NuRD) complex as interaction partners, implicating DVE-1 in the coordination of NuRD complex activity in the context of telomere organization.2026/06/23GSE333583GSM9769499GSM9769500GSM9769498GSM9769503GSM9769501GSM976950213657333583Caenorhabditis elegans