{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333794/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Saccharolobus islandicus REY15A"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333794"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Insights into the impact of archaeal proteasome activity on cell division: CCTF1 plays a decisive role in regulating cellular proteasome activity [CCTF1 OE]","description":"The cell cycle is a precisely coordinated series of events of cell growth, DNA replication and cell division, all of which are imperative for the proliferation of organisms. Archaea of the order Sulfolobales exhibit a cell cycle similar to that of eukaryotes. It has been suggested that the proteasome degradation of the cell division protein CdvB controls the progression of cell division. This raises a question regarding the regulation of proteosome activity in these archaea. In this paper, we report that an ArsR family cyclically-transcribed cell cycle transcription factor, CCTF1 (cell cycle transcription factor 1), plays a decisive role in regulation of the proteasome activity. We revealed that transcription of the proteasome regulatory subunit PAN (proteasome-activating nucleotidase) is specifically regulated by CCTF1 through binding to an AT-rich palindromic sequence. We show that CCTF1, rather than aCcrK (ePK2), is the key factor controlling the proteasome activity. Our study provides important insights into the proteosome-mediated cell cycle regulation mechanism in archaea.","dates":{"publication":"2026/08/01"},"accession":"GSE333794","cross_references":{"GSM":["GSM9773451","GSM9773453","GSM9773452","GSM9773455","GSM9773454","GSM9773456"],"GPL":["36531"],"GSE":["333794"],"taxon":["Saccharolobus islandicus REY15A"]}}