GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333794/primaryOK200TranscriptomicsSaccharolobus islandicus REY15AExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333794GEOGSEfalseInsights into the impact of archaeal proteasome activity on cell division: CCTF1 plays a decisive role in regulating cellular proteasome activity [CCTF1 OE]The cell cycle is a precisely coordinated series of events of cell growth, DNA replication and cell division, all of which are imperative for the proliferation of organisms. Archaea of the order Sulfolobales exhibit a cell cycle similar to that of eukaryotes. It has been suggested that the proteasome degradation of the cell division protein CdvB controls the progression of cell division. This raises a question regarding the regulation of proteosome activity in these archaea. In this paper, we report that an ArsR family cyclically-transcribed cell cycle transcription factor, CCTF1 (cell cycle transcription factor 1), plays a decisive role in regulation of the proteasome activity. We revealed that transcription of the proteasome regulatory subunit PAN (proteasome-activating nucleotidase) is specifically regulated by CCTF1 through binding to an AT-rich palindromic sequence. We show that CCTF1, rather than aCcrK (ePK2), is the key factor controlling the proteasome activity. Our study provides important insights into the proteosome-mediated cell cycle regulation mechanism in archaea.2026/08/01GSE333794GSM9773451GSM9773453GSM9773452GSM9773455GSM9773454GSM977345636531333794Saccharolobus islandicus REY15A