{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333903/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333903"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Human metapneumovirus and mumps virus alter the m6A landscapes in THP-1-derived immature dendritic cells","description":"N6-methyladenosine (m6A) is a widespread mRNA modification that regulates RNA metabolism and influences virus-induced immune responses. We performed MeRIP-seq to profile m6A landscapes in THP-1-derived immature dendritic cells (THP-iDCs) before and after infection with Human metapneumovirus (hMPV, NL/00/1) or mumps virus (MuV, JL2). Integration of m6A modifications on key innate immune transcripts with transcriptomic data, together with m6A levels on cellular and viral RNA, revealed a dual role of m6A in viral replication and host immune regulation. These datasets provide a resource for exploring epitranscriptomic regulation during hMPV and MuV infection.","dates":{"publication":"2026/07/10"},"accession":"GSE333903","cross_references":{"GSM":["GSM9777079","GSM9777078","GSM9777077","GSM9777087","GSM9777076","GSM9777086","GSM9777085","GSM9777084","GSM9777083","GSM9777082","GSM9777081","GSM9777080"],"GPL":["29480"],"GSE":["333903"],"taxon":["Homo sapiens"]}}