{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334496/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334496"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy","description":"EIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). To investigate its role in DR, human retinal pigment epithelial cells (ARPE-19) were exposed to 50 mM glucose to model the condition. Under hyperglycemic conditions, EIF1 was knocked down using siRNA, followed by transcriptome sequencing (RNA-seq) to profile differentially expressed genes (DEGs) and alternative splicing events (ASEs).","dates":{"publication":"2026/06/08"},"accession":"GSE334496","cross_references":{"GSM":["GSM9789677","GSM9789675","GSM9789676","GSM9789673","GSM9789674","GSM9789672"],"GPL":["24676"],"GSE":["334496"],"taxon":["Homo sapiens"]}}