GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334496/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334496GEOGSEfalseEIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathyEIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). To investigate its role in DR, human retinal pigment epithelial cells (ARPE-19) were exposed to 50 mM glucose to model the condition. Under hyperglycemic conditions, EIF1 was knocked down using siRNA, followed by transcriptome sequencing (RNA-seq) to profile differentially expressed genes (DEGs) and alternative splicing events (ASEs).2026/06/08GSE334496GSM9789677GSM9789675GSM9789676GSM9789673GSM9789674GSM978967224676334496Homo sapiens