{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334500/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334500"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Psychotropic-drug and neurotransmitter perturbation RNA-seq of human iPSC-derived cardiac and retinal organoids (ToxiPred)","description":"Bulk 3'-barcoded RNA-sequencing (Drop-seq-style digital gene expression) of human iPSC-derived cardiac and retinal organoids treated for 24 h at 5 uM with psychotropic drugs (aripiprazole, loxapine, sertraline, quetiapine, xanomeline) versus a No_drug reference, each crossed with neurotransmitter / co-treatment conditions (adrenaline, dopamine, histamine, retinoic acid, serotonin) plus vehicle/chemical controls. Generated for the ToxiPred study to test predicted tissue-resolved drug liability and recover lipid/sterol pathway mechanisms.","dates":{"publication":"2026/06/09"},"accession":"GSE334500","cross_references":{"GSM":["GSM9789754","GSM9789710","GSM9789711","GSM9789755","GSM9789752","GSM9789796","GSM9789753","GSM9789794","GSM9789750","GSM9789751","GSM9789795","GSM9789792","GSM9789793","GSM9789718","GSM9789719","GSM9789716","GSM9789717","GSM9789714","GSM9789758","GSM9789715","GSM9789759","GSM9789712","GSM9789756","GSM9789757","GSM9789713","GSM9789709","GSM9789790","GSM9789791","GSM9789765","GSM9789721","GSM9789722","GSM9789766","GSM9789763","GSM9789720","GSM9789764","GSM9789761","GSM9789762","GSM9789760","GSM9789729","GSM9789727","GSM9789728","GSM9789725","GSM9789769","GSM9789726","GSM9789723","GSM9789767","GSM9789768","GSM9789724","GSM9789732","GSM9789776","GSM9789777","GSM9789733","GSM9789774","GSM9789730","GSM9789731","GSM9789775","GSM9789772","GSM9789773","GSM9789770","GSM9789771","GSM9789738","GSM9789739","GSM9789736","GSM9789737","GSM9789734","GSM9789778","GSM9789735","GSM9789779","GSM9789743","GSM9789787","GSM9789788","GSM9789744","GSM9789785","GSM9789741","GSM9789742","GSM9789786","GSM9789783","GSM9789740","GSM9789784","GSM9789781","GSM9789782","GSM9789707","GSM9789708","GSM9789705","GSM9789749","GSM9789706","GSM9789703","GSM9789747","GSM9789748","GSM9789704","GSM9789745","GSM9789789","GSM9789701","GSM9789702","GSM9789746","GSM9789780"],"GPL":["34295"],"GSE":["334500"],"taxon":["Homo sapiens"]}}