{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334501/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Pseudomonas aeruginosa PAO1"],"gds_type":["Genome variation profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334501"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Basis of Hcp-Dependent Toxin Delivery during Interbacterial Competition","description":"The type VI secretion system (T6SS) is a bacterial contractile nanomachine that translocates toxic effectors into neighboring cells, helping bacteria to survive in competitive environments. The core T6SS structural protein Hcp forms the inner tube and mediates the loading and delivery of diverse effectors. Yet, how wide-ranging effectors that lack classical secretion signals are selectively recruited to Hcp remains poorly understood. To better understand, using Pseudomonas aeruginosa H1-T6SS as a model, we performed deep mutational scanning to determine how Hcp accommodates and delivers distinct effectors.","dates":{"publication":"2026/06/20"},"accession":"GSE334501","cross_references":{"GSM":["GSM9789798","GSM9789799","GSM9789797","GSM9789802","GSM9789800","GSM9789801"],"GPL":["20786"],"GSE":["334501"],"taxon":["Pseudomonas aeruginosa PAO1"]}}