{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334519/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Danio rerio"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334519"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Folic acid alleviates X-ray irradiation-induced jaw malformation in zebrafish","description":"X-rays are a form of ionizing radiation that has sufficient energy to remove electrons from atoms, thereby creating potentially harmful ions. X-ray irradiation during organogenesis can have profound detrimental effects, depending on the developmental stage and irradiating energy. In this study, we examined the impact of X-ray irradiation on zebrafish development at 36 h post-fertilization and observed marked jaw malformation, which was alleviated by folic acid pretreatment. Mechanistic studies revealed that folic acid pretreatment suppressed irradiation-induced production of reactive oxygen species. Transcriptome analysis performed at 24 h and 48 h post-irradiation revealed dysregulated expression of apolipoprotein A-IV a (apoa4a), methionine adenosyltransferase 1A (mat1a), heat shock protein 90 alpha class A member 1 tandem duplicate 1 (hsp90aa1.1), FKBP prolyl isomerase 5 (fkbp5), plac8 onzin related protein 3 (ponzr3), and prostaglandin E synthase 3a (ptges3a), which was not observed in zebrafish treated with folic acid-treated before the irradiation. These findings suggest that folic acid alleviates X-ray irradiation-induced jaw malformation in zebrafish, at least in part, by reducing oxidative stress and ameliorating dysregulated gene expression.","dates":{"publication":"2026/07/08"},"accession":"GSE334519","cross_references":{"GSM":["GSM9790226","GSM9790227","GSM9790228","GSM9790229","GSM9790190","GSM9790191","GSM9790192","GSM9790193","GSM9790194","GSM9790195","GSM9790196","GSM9790197","GSM9790230","GSM9790198","GSM9790231","GSM9790232","GSM9790199","GSM9790233","GSM9790234","GSM9790235","GSM9790236","GSM9790159","GSM9790215","GSM9790216","GSM9790217","GSM9790218","GSM9790219","GSM9790180","GSM9790181","GSM9790182","GSM9790183","GSM9790184","GSM9790185","GSM9790186","GSM9790220","GSM9790187","GSM9790221","GSM9790188","GSM9790189","GSM9790222","GSM9790223","GSM9790224","GSM9790225","GSM9790204","GSM9790248","GSM9790249","GSM9790205","GSM9790206","GSM9790207","GSM9790208","GSM9790209","GSM9790170","GSM9790171","GSM9790172","GSM9790173","GSM9790250","GSM9790174","GSM9790251","GSM9790252","GSM9790175","GSM9790176","GSM9790253","GSM9790177","GSM9790210","GSM9790254","GSM9790178","GSM9790211","GSM9790212","GSM9790179","GSM9790213","GSM9790214","GSM9790237","GSM9790238","GSM9790239","GSM9790160","GSM9790161","GSM9790162","GSM9790163","GSM9790240","GSM9790164","GSM9790241","GSM9790242","GSM9790165","GSM9790166","GSM9790243","GSM9790200","GSM9790244","GSM9790167","GSM9790201","GSM9790245","GSM9790168","GSM9790169","GSM9790246","GSM9790202","GSM9790203","GSM9790247"],"GPL":["23085"],"GSE":["334519"],"taxon":["Danio rerio"],"PMID":["[42385180]"]}}