GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334519/primaryOK200TranscriptomicsDanio rerioExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334519GEOGSEfalseFolic acid alleviates X-ray irradiation-induced jaw malformation in zebrafishX-rays are a form of ionizing radiation that has sufficient energy to remove electrons from atoms, thereby creating potentially harmful ions. X-ray irradiation during organogenesis can have profound detrimental effects, depending on the developmental stage and irradiating energy. In this study, we examined the impact of X-ray irradiation on zebrafish development at 36 h post-fertilization and observed marked jaw malformation, which was alleviated by folic acid pretreatment. Mechanistic studies revealed that folic acid pretreatment suppressed irradiation-induced production of reactive oxygen species. Transcriptome analysis performed at 24 h and 48 h post-irradiation revealed dysregulated expression of apolipoprotein A-IV a (apoa4a), methionine adenosyltransferase 1A (mat1a), heat shock protein 90 alpha class A member 1 tandem duplicate 1 (hsp90aa1.1), FKBP prolyl isomerase 5 (fkbp5), plac8 onzin related protein 3 (ponzr3), and prostaglandin E synthase 3a (ptges3a), which was not observed in zebrafish treated with folic acid-treated before the irradiation. These findings suggest that folic acid alleviates X-ray irradiation-induced jaw malformation in zebrafish, at least in part, by reducing oxidative stress and ameliorating dysregulated gene expression.2026/07/08GSE334519GSM9790226GSM9790227GSM9790228GSM9790229GSM9790190GSM9790191GSM9790192GSM9790193GSM9790194GSM9790195GSM9790196GSM9790197GSM9790230GSM9790198GSM9790231GSM9790232GSM9790199GSM9790233GSM9790234GSM9790235GSM9790236GSM9790159GSM9790215GSM9790216GSM9790217GSM9790218GSM9790219GSM9790180GSM9790181GSM9790182GSM9790183GSM9790184GSM9790185GSM9790186GSM9790220GSM9790187GSM9790221GSM9790188GSM9790189GSM9790222GSM9790223GSM9790224GSM9790225GSM9790204GSM9790248GSM9790249GSM9790205GSM9790206GSM9790207GSM9790208GSM9790209GSM9790170GSM9790171GSM9790172GSM9790173GSM9790250GSM9790174GSM9790251GSM9790252GSM9790175GSM9790176GSM9790253GSM9790177GSM9790210GSM9790254GSM9790178GSM9790211GSM9790212GSM9790179GSM9790213GSM9790214GSM9790237GSM9790238GSM9790239GSM9790160GSM9790161GSM9790162GSM9790163GSM9790240GSM9790164GSM9790241GSM9790242GSM9790165GSM9790166GSM9790243GSM9790200GSM9790244GSM9790167GSM9790201GSM9790245GSM9790168GSM9790169GSM9790246GSM9790202GSM9790203GSM979024723085334519Danio rerio[42385180]