{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334551/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334551"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"NAD+ Deficiency Drives Metabolic Dysfunction-Associated Atrial Fibrillation","description":"Atrial fibrillation (AF) is a cardiometabolic disease with obesity and diabetes as major risk factors. The cellular and molecular mechanisms by which obesity and metabolic stressors drive AF are poorly understood. Here we establish a new mouse model of spontaneous, obesity-induced AF. This two-hit model relies on genetic susceptibility coupled with an environmental factor of diet-induced obesity. Unbiased multi-omics analyses reveal cardiac conduction pathways, inflammation, and metabolic perturbations in AF. We demonstrate atrial NAD+ deficiency as a central pathological mediator in AF. Pharmacological replenishment of atrial NAD+ levels mitigates AF, protects against cardiac remodeling and fibrosis, reduces inflammation, and improves atrial metabolism. These results highlight the role of a metabolic pathway that could be therapeutically targeted for AF.","dates":{"publication":"2026/06/24"},"accession":"GSE334551","cross_references":{"GSM":["GSM9790743","GSM9790721","GSM9790744","GSM9790722","GSM9790723","GSM9790745","GSM9790746","GSM9790724","GSM9790747","GSM9790725","GSM9790726","GSM9790727","GSM9790728","GSM9790729","GSM9790730","GSM9790731","GSM9790732","GSM9790733","GSM9790734","GSM9790735","GSM9790736","GSM9790737","GSM9790738","GSM9790739","GSM9790719","GSM9790740","GSM9790741","GSM9790720","GSM9790742"],"GPL":["24247","34290"],"GSE":["334551"],"taxon":["Mus musculus"]}}