{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334586/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Heterocephalus glaber"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334586"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional profiling of the Epidermis of Naked Mole-RatsTreated with DMBA and TPA","description":"We compared expressions of cancer-related genes (tumor suppressor genes and oncogenes) in the skin epidermis between Naked mole-rats treated with DMBA/TPA and control animals. Bulk RNA-seq analyses revealed that in contrast to control animals, epidermis of Naked mole-rats treated with DMBA/TPA is characterized by increased expression of anti-cancer genes, activation of genes controlling ferroptosis, as well as by downregulation of numerous oncogenes including components of NF-kB, Wnt and tyrosine kinase signaling pathways.","dates":{"publication":"2026/07/09"},"accession":"GSE334586","cross_references":{"GSM":["GSM9791359","GSM9791360","GSM9791361","GSM9791356","GSM9791357","GSM9791358"],"GPL":["21195"],"GSE":["334586"],"taxon":["Heterocephalus glaber"]}}