GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334588/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334588GEOGSEfalseSingle-cell transcriptomic atlas of adult dermatomyositis, cutaneous lupus erythematosus and healthy skinAdult-onset dermatomyositis (DM) is a systemic autoimmune disease associated with an elevated risk of malignancy, yet the cellular and molecular features distinguishing cancer-associated DM from non-cancer DM remain poorly defined. Here, we conduct a comprehensive single-cell RNA sequencing analysis of adult-onset DM skin, including lesional and non-lesional samples, alongside cutaneous lupus erythematosus (CLE) and healthy control skin, to characterize immune and stromal cell states and disease-specific transcriptional programs. We identify distinct immune-stromal cell populations that differentiate cancer-associated DM from non-cancer-associated DM and CLE, including a vascular injury phenotype with hypoxia and metabolic reprogramming enriched in cancer-associated DM. These findings nominate cell-state-defining molecular features as potential biomarkers for cancer screening and therapeutic targeting in adult dermatomyositis.2026/06/08GSE334588GSM9791414GSM9791415GSM9791416GSM9791417GSM9791380GSM9791381GSM9791382GSM9791383GSM9791384GSM9791385GSM9791386GSM9791387GSM9791388GSM9791400GSM9791389GSM9791401GSM9791402GSM9791403GSM9791404GSM9791405GSM9791406GSM9791407GSM9791408GSM9791409GSM9791390GSM9791391GSM9791392GSM9791370GSM9791371GSM9791393GSM9791394GSM9791372GSM9791395GSM9791373GSM9791374GSM9791396GSM9791397GSM9791375GSM9791398GSM9791376GSM9791377GSM9791410GSM9791399GSM9791411GSM9791378GSM9791412GSM9791379GSM979141324676334588Homo sapiens