{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334702/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Bos taurus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334702"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Endometrial transcriptomic responses associated with a 17α-hydroxyprogesterone caproate-containing formulation and progesterone in Holstein cows: an exploratory RNA-seq analysis","description":"17α-hydroxyprogesterone caproate (17-OHPC) is included in a veterinary depot formulation approved in Japan for the prevention of implantation failure and abortion in cattle, but its molecular effects on the bovine endometrium remain unclear. In this exploratory RNA-seq study, six Holstein cattle were assigned to a 17-OHPC-containing formulation group (100 mg 17-OHPC plus 10 mg progesterone [P4]; n = 3) or a P4-alone group (100 mg P4; n = 3). Endometrial samples were collected during an untreated synchronized cycle on days 4 and 7, and during a second synchronized cycle on day 7 after treatment on day 4. RNA-seq was used to characterize treatment-associated endometrial transcriptomic profiles and gene-set enrichment patterns between the 17-OHPC/P4 formulation and P4-alone arms.","dates":{"publication":"2026/06/16"},"accession":"GSE334702","cross_references":{"GSM":["GSM9793824","GSM9793835","GSM9793823","GSM9793834","GSM9793826","GSM9793837","GSM9793836","GSM9793825","GSM9793828","GSM9793827","GSM9793829","GSM9793831","GSM9793820","GSM9793830","GSM9793833","GSM9793822","GSM9793821","GSM9793832"],"GPL":["28857"],"GSE":["334702"],"taxon":["Bos taurus"]}}