{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334769/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334769"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Immunogen-Sponge Hydrogel Reverses TIM-3–Mediated Dendritic-Cell Exhaustion in Alveolar Echinococcosis","description":"Alveolar echinococcosis (AE) induces profound dendritic-cell dysfunction characterized by elevated TIM-3 expression and impaired antigen presentation. To overcome parasite-induced immunosuppression, we developed a SHIFT-engineered Immunogen-Sponge hydrogel vaccine incorporating protoscolex-derived antigens (PSAs). Bone marrow-derived dendritic cells (BMDCs) were treated with saline, PSA, F127@PSA, or SHIFT-F127@PSA and subjected to transcriptome sequencing. Comparative transcriptomic analyses were performed to investigate dendritic-cell activation, antigen presentation, immune signaling pathways, and TIM-3-associated regulatory mechanisms.","dates":{"publication":"2026/08/08"},"accession":"GSE334769","cross_references":{"GSM":["GSM9796849","GSM9796848","GSM9796850","GSM9796843","GSM9796854","GSM9796853","GSM9796852","GSM9796851","GSM9796847","GSM9796846","GSM9796845","GSM9796844"],"GPL":["28330"],"GSE":["334769"],"taxon":["Mus musculus"]}}