{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334781/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Staphylococcus aureus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334781"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The ‘Metabolic Trap’: Candida parapsilosis Inhibits Staphylococcus aureus Biofilm Maturation by Disrupting pH Homeostasis and Inducing Premature Exodus","description":"Biofilms are surface-attached communities of microorganisms surrounded by an extracellular matrix. The biofilm matrix plays an integral role in protecting the microorganisms within. Biofilm infections are incredibly difficult to treat. Staphylococcus aureus is a major human pathogen and can produce robust biofilm. Candida parapsilosis is an emerging fungal pathogen that is frequently isolated as the cause of infection. Its interaction with S. aureus has yet to be explored. The aim of this experiment was to characterise the transcriptional effects that occur in S. aureus during co-culture with C. parapsilosis cells or C. parapsilosis cell-free supernatant. RNA sequencing identified global changes in transcription that occur in S. aureus in the presence of C. parapsilosis cells or cell-free supernatant.","dates":{"publication":"2026/06/23"},"accession":"GSE334781","cross_references":{"GSM":["GSM9797022","GSM9797033","GSM9797032","GSM9797021","GSM9797031","GSM9797020","GSM9797030","GSM9797026","GSM9797025","GSM9797024","GSM9797023","GSM9797019","GSM9797029","GSM9797028","GSM9797027"],"GPL":["27158"],"GSE":["334781"],"taxon":["Staphylococcus aureus"]}}