{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334791/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334791"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of depletion of Nsd1 or Ezh2 on gene expression during pluripotency transition","description":"CRISPR Screen with single-cell RNA-Seq as readout reveals new epigenetic factors regulate pluripotency of m ESCs. This highly sensitive method identified key genes essential for the acquisition and exit from pluripotency, and revealed loss of Nsd1-mediated H3K36me2 delayed exit from the naive state, while loss of Ezh2-mediated H3K27me3 promoted transition to the primed state.","dates":{"publication":"2026/07/15"},"accession":"GSE334791","cross_references":{"GSM":["GSM9797110","GSM9797112","GSM9797111","GSM9797107","GSM9797106","GSM9797105","GSM9797109","GSM9797108"],"GPL":["13112"],"GSE":["334791"],"taxon":["Mus musculus"]}}