GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334791/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334791GEOGSEfalseEffect of depletion of Nsd1 or Ezh2 on gene expression during pluripotency transitionCRISPR Screen with single-cell RNA-Seq as readout reveals new epigenetic factors regulate pluripotency of m ESCs. This highly sensitive method identified key genes essential for the acquisition and exit from pluripotency, and revealed loss of Nsd1-mediated H3K36me2 delayed exit from the naive state, while loss of Ezh2-mediated H3K27me3 promoted transition to the primed state.2026/07/15GSE334791GSM9797110GSM9797112GSM9797111GSM9797107GSM9797106GSM9797105GSM9797109GSM979710813112334791Mus musculus