{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334853/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334853"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal single-cell RNA sequencing of PBMCs from a Guillain–Barré syndrome patient before and after IVIg treatment","description":"Peripheral blood mononuclear cells (PBMCs) were collected longitudinally from a patient with Guillain–Barré syndrome (GBS) before and after intravenous immunoglobulin (IVIg) treatment. Single-cell RNA sequencing was performed to characterize treatment-associated immune remodeling at single-cell resolution. The study identified stage-dependent transcriptional changes in plasma cells, monocytes, B cells, and double-negative T cells, revealing alterations in inflammatory, humoral, and cytokine-mediated immune pathways.","dates":{"publication":"2026/09/02"},"accession":"GSE334853","cross_references":{"GSM":["GSM9798510","GSM9798509"],"GPL":["24676"],"GSE":["334853"],"taxon":["Homo sapiens"],"PMID":["[42661746]"]}}