{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334860/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334860"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome analysis of circSmad5 knockdown in immortalized hair follicle stem cells (iHFSC2)","description":"To investigate the role ofcircSmad5 in hair follicle stem cells (HFSCs), we performed RNA-seq on iHFSC2 cells with circSmad5 knockdown (shcircSmad5) versus empty vector control. Knockdown of circSmad5 increased hair count in a hair reconstitution model and activated Wnt/β-catenin and Mrs/Erk signaling pathways. This study provides transcriptomic insights into how circSmad5 regulates HFSC stemness and differentiation.","dates":{"publication":"2026/06/09"},"accession":"GSE334860","cross_references":{"GSM":["GSM9798680","GSM9798681"],"GPL":["21103"],"GSE":["334860"],"taxon":["Mus musculus"]}}