GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334860/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334860GEOGSEfalseTranscriptome analysis of circSmad5 knockdown in immortalized hair follicle stem cells (iHFSC2)To investigate the role ofcircSmad5 in hair follicle stem cells (HFSCs), we performed RNA-seq on iHFSC2 cells with circSmad5 knockdown (shcircSmad5) versus empty vector control. Knockdown of circSmad5 increased hair count in a hair reconstitution model and activated Wnt/β-catenin and Mrs/Erk signaling pathways. This study provides transcriptomic insights into how circSmad5 regulates HFSC stemness and differentiation.2026/06/09GSE334860GSM9798680GSM979868121103334860Mus musculus