{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334949/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Drosophila melanogaster"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334949"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Notch Signaling Reprograms Glial Lipid Metabolism to Promote Hypoxia Resistance","description":"To understand the transcriptional basis of Notch activation-conferred hypoxia tolerance, we performed single-nucleus RNA sequencing (snRNA-seq) of the developing Drosophila central nervous system and generated a comprehensive cellular atlas at single-cell resolution. Analysis of Eaat1-expressing cells revealed that Notch activation reshaped hypoxia-induced transcriptional responses and counteracted metabolic suppression caused by low oxygen. Together, our findings identify Eaat1 glia as a metabolically adaptive glial population and reveal a conserved Notch-regulated mechanism that rewires lipid metabolism to support hypoxia tolerance in the developing brain.","dates":{"publication":"2026/06/26"},"accession":"GSE334949","cross_references":{"GSM":["GSM9802556","GSM9802555","GSM9802554","GSM9802553"],"GPL":["34457"],"GSE":["334949"],"taxon":["Drosophila melanogaster"]}}