GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334977/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334977GEOGSEfalseSevere hyperchylomicronemia sensitizes the heart to pathological remodeling: evidence from GPIHBP1 deficient miceThis dataset contains bulk RNA sequencing data generated from cardiac tissues of wild-type (WT) and Gpihbp1 knockout (Gpihbp1−/−) mice. GPIHBP1 deficiency disrupts intravascular triglyceride-rich lipoprotein hydrolysis and results in severe hyperchylomicronemia. To investigate the molecular changes associated with chronic triglyceride-rich lipoprotein accumulation in the heart, total RNA was isolated from cardiac tissues and subjected to high-throughput transcriptome sequencing. These data provide a resource for characterizing gene expression alterations and biological pathways associated with cardiac metabolic remodeling, mitochondrial dysfunction, and heart failure susceptibility in the setting of severe hypertriglyceridemia.2026/06/15GSE334977GSM9802943GSM9802942GSM9802941GSM9802940GSM9802939GSM9802938GSM9802937GSM980293628330334977Mus musculus